发明名称 |
3-ALKYLARYL ASPARTATE COMPOUNDS AND THEIR USE FOR SELECTIVE ENHANCEMENT OF SYNAPTIC TRANSMISSION |
摘要 |
The present invention provides an L-aspartate derivative compound represented by the following structure (I) wherein Ar represents an aromatic group; L represents a linking moiety; R represents hydrogen, alkyl, aryl, or heteroaryl; and ~~~ indicates that the stereochemistry at the 3-position can be R or S. The compounds of the invention are useful for selectively inhibiting EAAT3 and for enhancing synaptic transmission. Additionally, the inventive compounds can be used to treat a patient suffering from Alzheimers disease or a neuropathy or a neurodegenerative disease in which L-glutamate transporter activity is involved in the onset of the disease. |
申请公布号 |
WO2006047251(A3) |
申请公布日期 |
2006.07.06 |
申请号 |
WO2005US37823 |
申请日期 |
2005.10.21 |
申请人 |
THE UNIVERSITY OF MONTANA;ESSLINGER, CHRISTOPHER S.;BRIDGES, RICHARD J.;KAVANAUGH, MICHAEL P. |
发明人 |
ESSLINGER, CHRISTOPHER S.;BRIDGES, RICHARD J.;KAVANAUGH, MICHAEL P. |
分类号 |
C07C229/36;A61K31/195;A61P25/28 |
主分类号 |
C07C229/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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