The total asymmetric synthesis of the cytotoxic marine metabolite (-)-agelastatin A (I) has been achieved from a 4,5-diamino-cyclopenten-2-one derived intermediate. This key intermediate was efficiently prepared from a sulfinimine-derived alpha-beta-diamino ester using ring closing metathesis.
申请公布号
WO2006055578(A3)
申请公布日期
2006.07.06
申请号
WO2005US41418
申请日期
2005.11.16
申请人
HIGHER EDUCATION TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEMS OF;DAVIS, FRANKLIN, A.;DENG, JIANGHE