发明名称 |
Oncolytic adenovirus armed with therapeutic genes |
摘要 |
The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway. |
申请公布号 |
US2006147420(A1) |
申请公布日期 |
2006.07.06 |
申请号 |
US20050077513 |
申请日期 |
2005.03.10 |
申请人 |
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发明人 |
FUEYO JUAN;GOMEZ-MANZANO CANDELARIA;YUNG W.K. A.;CONRAD CHARLES A.;LANG FREDERICK F.JR. |
分类号 |
A61K48/00;C07K14/075;C12N15/861 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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