| 摘要 |
PROBLEM TO BE SOLVED: To develop drug(s) in view of the fact that neurodegenerative diseases including Alzheimer's disease, senile dementia, cerebrovascular dementia and Parkinson's disease means symptoms presenting disorders in memory and/or cognizance by neural network failure with various causes, and for these diseases with no effective curative methods, such treatments as to enable neurological functions to be brought to conditions close to normal state have been demanded even from conditions being already in progression of neural network disorders. SOLUTION: In cultured neurocytes, such conditions as to present the atrophy in neurites and dendrites and decrease in presynapse number and postsynapse number are created. The objective drug(s) capable of restoring neurocyte dendrites and synapse to normal conditions by treating neurocytes in the above-mentioned conditions is(are) retrieved from among components in traditional drugs, and withanosides and sominone as a metabolite thereof are identified. Furthermore, it is found that the above metabolite and/or an astragaloside metabolite is(are) useful as neural network reconstructive agent(s). COPYRIGHT: (C)2006,JPO&NCIPI
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