LIPOSOMAL FORMULATIONS OF THE ANTINEOPLASTIC AGENTS

摘要

The invention relates to the liposomal formulation of an antineoplastic agent encapsulated in the liposomal vesicles which are the composition of lipid components, wherein the ratio of a therapeutically active agent to the lipid components is between about 1:10 and about 1:30 (w/w). The composition of lipid components contains at least one phospholipid derivative and at least one alkylphenol derivative presented by a general formula (I) , wherein: n is an integer 1 - 17; m is an integer 0-15; X is -C=O, -0- or a bond; Y is a group of formula -NR₂R₃, a monosaccharide moiety or a bond; Z is H, -0-, -N-, -OR₄, -NR₄ or a monosaccharide moiety, R₅ is H or COOH.