摘要 |
<p>The present invention provides improved systems and methods for the local delivery of H2 antagonists. The inventive methods include topical administration of an effective amount of a H2 antagonist encapsulated in liposomes. In certain embodiments, the H2 antagonist, for example, Cimetidine, is encapsulated into paucilamellar liposomes, such as NOVASOME<SUP>®</SUP> microvesicles. Also provided are pharmaceutical compositions comprising liposome-encapsulated H2 antagonists. The methods and compositions of the present invention may be used to treat any disease state or condition where local administration of H2 antagonists is beneficial.</p> |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY;VAN DYKE, THOMAS, E.;HOLICK, MICHAEL;KANTARCI, ALPDOGAN;HASTURK, HATICE |
发明人 |
VAN DYKE, THOMAS, E.;HOLICK, MICHAEL;KANTARCI, ALPDOGAN;HASTURK, HATICE |