发明名称 |
MONOMERIC RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T CELLS |
摘要 |
<p>The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class II component. The modified RTLs have redesigned surface features that preclude or reduce aggregation, wherein the modified molecules retain the ability to bind Ag-peptides, target antigen-specific T cells, inhibit T cell proliferation in an Ag-specific manner and have utility to treat, inter alia, autoimmune disease and other conditions mediated by antigen-specific T cells in vivo.</p> |
申请公布号 |
EP1675607(A2) |
申请公布日期 |
2006.07.05 |
申请号 |
EP20040816845 |
申请日期 |
2004.09.07 |
申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
BURROWS, GREGORY, G.;VANDENBARK, ARTHUR, A. |
分类号 |
A61K38/16;A61K39/00;A61K39/395;C07H21/04;C07K14/74;C12N;C12N5/08;C12Q1/68;(IPC1-7):A61K38/16 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|