发明名称 |
METHOD FOR THE PREPARATION OF 2'-DEOXY-2',2'-DIFLUOROCYTIDINE |
摘要 |
<p>Provided is an improved method for stereoselectively preparing 2′-deoxy-2′,2′-difluorocytidine of formula (I), which includes reacting a 1-halo ribofuranose compound with a nucleobase of formula (IV) in a solvent to obtain a nucleo side of formula (II) with removal of a silyl halide ((alkyl)3SiX (X=halide)); and deprotecting the nucleoside of formula (II) to obtain 2′-deoxy-2′,2′-difluorocytidine of formula (I). 2′-Deoxy-2′,2′-difluorocytidine of formula (I) is effective for treating various cancers such as non-small cell lung (NSCLC), pancreatic, bladder, breast or ovarian cancers.</p> |
申请公布号 |
KR20060079099(A) |
申请公布日期 |
2006.07.05 |
申请号 |
KR20050129573 |
申请日期 |
2005.12.26 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
LEE, JAE HEON;PARK, GHA SEUNG;LEE, MOON SUB;BANG, HYO JEONG;LEE, JAE CHUL;KIM, CHEOL KYONG;CHOI, CHANG JU;KIM, HAN KYONG;LEE, HOE CHUL;CHANG, YOUNG KIL;LEE, GWAN SUN |
分类号 |
C07H19/04;C07D405/04 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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