Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine

摘要

A coating for an implantable medical device is disclosed. The coating comprises a polymer and an amino acid chemically bonded, attached or conjugated to the polymer. In one embodiment, the coating can include a therapeutic substance. In lieu of bonding the amino acid to the polymer, the amino acid can be chemically bonded to the therapeutic substance or both the substance and the polymer. The amino acid can be polymers and/or oligomers of L-arginine, and copolymers of L-arginine with lysine. The coating can optionally include a nitric oxide donor, such as diazenium diolate type nitric oxide donors, chemically conjugated to the amino acid.