| 摘要 |
A method of producing gabapentin (1-amino-methyl)-1-cyclohexaneacetic acid) from its hydrochloric salt in an anhydrous medium, the method consisting of: dissolving gabapentin hydrochloride in a non-aqueous organic solvent in which gabapentin is insoluble to obtain a solution of gabapentin hydrochloride; adding an epoxide to the solution to remove the chloride ions thereby precipitating gabapentin out of the solution as a white solid; recovering the white solid by filtration; and drying the white solid.
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