发明名称 |
Small organic molecules that increase the activity of gelatinase a in ocular cells |
摘要 |
Small organic molecules capable of effecting a "pharmacological trabeculocanalotomy" in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increasing cell membrane expression of membrane-type matrix metalloproteinases (MT-MMPs) to increase aqueous outflow as a treatment for primary open angle glaucoma.
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申请公布号 |
US7071211(B2) |
申请公布日期 |
2006.07.04 |
申请号 |
US20020260448 |
申请日期 |
2002.09.27 |
申请人 |
BAUSCH & LOMB INC. |
发明人 |
PFEFFER BRUCE ALAN;FLICK ROSEMARIE BETH;KAMAL SHAMS NAVEED BIN;BARTELS STEPHEN PAUL |
分类号 |
A61K31/4453;C07C275/10;C07C281/18;C07D207/02;C07D211/02;C07D223/26;C07D279/22;C07D295/205 |
主分类号 |
A61K31/4453 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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