Use of vitamin D-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin D3-derivatives

摘要

Compounds of the formula I wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O₂); R¹ and R², which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated, C₁-C₆-hydrocarbon; or R¹ and R², together with the carbon atom to which they are attached (marked with an asterisk in formula I), bearing the group X, form a C₃-C₈ carbocyclic ring; Q represents a diradical residue after removal of 2 hydrogen atoms from a straight, branched or cyclic, saturated or unsaturated C₁-C₈-hydrocarbon; and R³ represents hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated C₁-C₆-hydrocarbon; may be used for the preparation of a medicament for the treatment and/or prophylaxis of osteoporosis and related bone disorders.