| 摘要 |
Tablets for oral administration comprise a) a first layer 1 that swells noticeably and rapidly on contact with aqueous biological fluids, the layer being prepared by compression of a mixture or granules having 5 - 90% by weight (pref. 10 - 85%) of hydrophilic polymers, b) a second layer 2 that is adjacent to or superposed on 1, containing alfuzosin hydrochloride (I), hydrophilic polymers, and auxiliary materials that give the mixture compressibility whilst allowing liberation of (I) over a predetermined period, and optionally c) a third layer 3 that is compressed and applied over 2 which is mainly hydrophilic polymers that gel and/or swell and which may erode, having the effect of modifying liberation of (I) from layer 2, this layer 3 being only slightly permeable to (I) these tablets giving controlled liberation of (I) at the proximal segments of the gastrointestinal tract (duodenum and jejunum). |
