| 摘要 |
A 3'-substituted-beta-L-nucleoside of formula (I), and a pharmaceutically acceptable salt thereof is disclosed, wherein R1 is hydrogen, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, akylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; R2 is selected from the group consisting of straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-substituted aryl, arylsulfonyl, aralkylsulfonyl, mono, di, or triphosphate, or a phosphate derivative; X is O, S, SO2 or CH2; and BASE is a purine or pyrimidine base that may optionally be substituted. Also disclosed is the use of such a compound in the manufacture of a medicament for the treatment or prophylaxis of a hepatitis B virus infection in a host.
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