Amide substituted imidazopyridines and pharmaceuticals for inducing cytokine biosynthesis and treating viral and neoplastic diseases

摘要

A compound of formula (I) is described wherein: X is alkylene or alkenylene; Y is -CO- or -CS-; Z is a bond or-O- or -S- R1 is aryl, heteroaryl, heterocyclyl, alkyl or alkenyl each which may be unsubstituted or substituted; R2 is selected from H, alkyl, alkenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkyl-O-alkyl, alkyl-S-alkyl, alkyl-O-aryl, alkyl-S-aryl, alkyl-O-alkenyl, alkyl-S-alkenyl and alkyl or alkenyl substituted; R3 and R4 are selected from hydrogen, alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialkylamino and alkylthio; R5 is H or C1-10 alkyl, or R5 can join with X to form a ring that contains one or two hetero atoms; or when R1 is alkyl, R5 and R1 can join to forma ring R6 is H or C1-10alkyl. A pharmaceutical composition comprising the compound is useful for inducing cytokine biosynthesis, in treating viral disease and for treating a neoplastic disease. Also described is a compound of formula (II) wherein: X is alkylene or alkenylene; R5 is H or C1-10 alkyl, or R5 can join with X to form a ring that contains one or two hetero atoms; and R2, R3, R4 and R6 are as defined above.