We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.
申请公布号
WO2006069339(A2)
申请公布日期
2006.06.29
申请号
WO2005US46869
申请日期
2005.12.21
申请人
ACADEMIA SINICA;CHENG, YAUN-TSONG;YUAN, HSIANG-YU;CHEN, JIN-JER