发明名称 |
USE OF 2-PHENYL-1, 2-ETHANEDIOL- (DI) CARBAMATES FOR TREATING EPILEPTOGENESIS AND EPILEPSY |
摘要 |
This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof,: Formula (I) Formula (II) wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB> and R<SUB>6</SUB> are independently selected from the group consisting of hydrogen and C<SUB>1</SUB>-C<SUB>4</SUB> alkyl; wherein C<SUB>1</SUB>-C<SUB>4</SUB> alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C<SUB>1</SUB>-C<SUB>4</SUB> alkyl, C<SUB>1</SUB>-C<SUB>4</SUB> alkoxy, amino, nitro and cyano). |
申请公布号 |
WO2006033947(A3) |
申请公布日期 |
2006.06.29 |
申请号 |
WO2005US32861 |
申请日期 |
2005.09.15 |
申请人 |
JANSSEN PHARMACEUTICA, N.V.;CHOI, YONG MOON;GORDON, ROBERT;NOVAK, GERALD P.;PLATA-SALAMAN, CARLOS R.;TWYMAN, ROY E;WHITE, H. STEVE;ZHAO, BOYU |
发明人 |
CHOI, YONG MOON;GORDON, ROBERT;NOVAK, GERALD P.;PLATA-SALAMAN, CARLOS R.;TWYMAN, ROY E;WHITE, H. STEVE;ZHAO, BOYU |
分类号 |
A61K31/27 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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地址 |
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