METHOD OF PRODUCING POTASSIUM [18F] FLUORIDE AND QUATERNARY AMMONIUM [18F] FLUORIDE AND METHOD OF PRODUCING RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND BY USING THE SAME

摘要

[PROBLEMS] To prevent the formation of impurities caused by the decomposition of a substrate in the process of producing a radioactive fluorine-labeled compound. [MEANS FOR SOLVING PROBLEMS] A method of producing potassium [<SUP>18</SUP>F] fluoride or quaternary ammonium [<SUP>18</SUP>F] fluoride characterized by comprising the step of contacting <SUP>18</SUP>O-concentrated water containing [<SUP>18</SUP>F] fluoride ion with a strongly acidic cation exchange resin and thus removing cationic impurities, the next step of contacting the <SUP>18</SUP>O-concentrated water with a weakly basic anion exchange resin and thus allowing the weakly basic anion exchange resin to adsorb the [<SUP>18</SUP>F] fluoride ion, and the step of eluting the [<SUP>18</SUP>F] fluoride ion having been adsorbed by the weakly basic anion exchange resin with the use of an aqueous solution of a potassium salt (excluding potassium carbonate and potassium hydrogencarbonate) or a solution of a quaternary ammonium salt (excluding hydrogen carbonate). A method of producing a radioactive fluorine-labeled organic compound which involves the step of labeling an organic compound with the use of the potassium [<SUP>18</SUP>F] fluoride or quaternary ammonium [<SUP>18</SUP>F] fluoride obtained by the above-described production method.