POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS

摘要

Compounds and methods for utilizing compounds comprising a superoxide
dismutase mimetic covalently linked to polyethylene glycol. Methods are also
provided for preparing a superoxide dismutase mimetic covalently linked to a
polyethylene glycol, the methods comprising reacting an activated polyethylene
glycol with a superoxide dismutase mimetic, or alternatively, reacting a
superoxide dismutase mimetic with an activated polyethylene glycol. A method
is also provided for preventing or treating a disease or disorder in which
superoxide anions are implicated, comprising administering to a subject in
need thereof, a therapeutically effective amount of a compound comprising a
superoxide dismutase mimetic covalently linked to a polythylene glycol.
Methods of determining the safety and efficacy of the compounds are also
provided. Methods for determining the safety and efficacy can include methods
in lab animals and humans.