发明名称 |
8-AZA-BICYCLO (3.2.1) OCTANE DERIVATIVES WITH AN ACTIVITY ON CHEMOKINE CCR5 RECEPTORS |
摘要 |
<p>The present invention provides compounds of formula (I) R<SUP>3</SUP>,<SUP/>(I) wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.</p> |
申请公布号 |
WO2006067584(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
WO2005IB03822 |
申请日期 |
2005.12.12 |
申请人 |
PFIZER LIMITED;PRYDE, DAVID, CAMERON;STUPPLE, PAUL, ANTHONY |
发明人 |
PRYDE, DAVID, CAMERON;STUPPLE, PAUL, ANTHONY |
分类号 |
C07D451/04;A61K31/46;A61P31/18;C07D471/04 |
主分类号 |
C07D451/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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