发明名称 |
mRNA ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer |
摘要 |
Described herein are methods and kits for prognosis of prostate cancer in a subject. The methods comprises: (a) determining the ratio of PCA3 and PSA expression in a urine sample and (b) correlating the value of the PCA3/PSA ratio with the aggressiveness and mortality risk of prostate cancer in the subject. Kits for prognosing prostate cancer are also described. More particularly, the present invention features a method for prognosing prostate cancer in a biological sample of a patient comprising: assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of PSA in the biological sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of PSA; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value. |
申请公布号 |
AU2005318369(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
AU20050318369 |
申请日期 |
2005.12.23 |
申请人 |
STICHTING, KATHOLIEKE UNIVERSITEIT, THE UNIVERSITY MEDICAL |
发明人 |
GERALD VERHAEGH;ALFRED J. WITJES;JACK A. SCHALKEN;DAPHNE HESSELS |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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