发明名称 |
Process for obtaining enantiomers of Cizolirtine |
摘要 |
A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric reduction of a prochiral ketone in the presence of a chiral ruthenium (II) catalyst system including at least a bidentate phosphorous-containing ligand and a diamine ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield corresponding pharmaceutically active ethanamines.
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申请公布号 |
US2006142589(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
US20050041667 |
申请日期 |
2005.01.24 |
申请人 |
TORRENS JOVER ANTONI;BUSCHMANN HELMUT H;HELLER DETLEFF;DREXLER HANS J |
发明人 |
TORRENS JOVER ANTONI;BUSCHMANN HELMUT H.;HELLER DETLEFF;DREXLER HANS J. |
分类号 |
C07D231/12 |
主分类号 |
C07D231/12 |
代理机构 |
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地址 |
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