摘要 |
The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase. |
申请人 |
MEIJI SEIKA KAISHA LTD., TOKIO/TOKYO |
发明人 |
MIDOH, NAOKI;OKAKURA, KAORU;MIYAMOTO, KOICHI;WATANABE, MANABU;YANAI, KOJI;YASUTAKE, TETSUYA;AIHARA, SATO;FUTAMURA, TAKAFUMI;KLEINKAUF, HORST;MURAKAMI, TAKESHI |