摘要 |
<p>The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.</p> |
申请人 |
NOVO NORDISK HEALTH CARE AG;KRARUP, JANUS;HANSEN, THOMAS BUDDE;ARENTSEN, ANNE, CHARLOTTE;RASMUSSEN, DANIEL, E.;BOGSNES, ARE;STABY, ARNE;AHMADIAN, HALEH;BANG, SUSANNE |
发明人 |
KRARUP, JANUS;HANSEN, THOMAS BUDDE;ARENTSEN, ANNE, CHARLOTTE;RASMUSSEN, DANIEL, E.;BOGSNES, ARE;STABY, ARNE;AHMADIAN, HALEH;BANG, SUSANNE |