INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF ANGIOTENSIN II RECEPTOR ANTAGONISTS
摘要
It comprises new substituted heterocyclic methylphenyl boronic acids and their derivatives and also its preparation process. It also comprises a preparation process of Angiotensin II (A-II) receptor antagonists from such intermediates. The process includes the step of reacting the new substituted heterocyclic methylphenyl boronic compounds with a (halophenyl)tetrazole compound which proceeds with high yields. It allows to prepare the compounds of the present invention from a common intermediate compound, a N-protected- 5-(2-halogenphenyl)-1H-tetrazole, by a process which is particularly advantageous in its practical industrial realization because it avoids the use of azide derivatives and also the use of expensive biphenyl intermediates.
申请公布号
WO2006067215(A2)
申请公布日期
2006.06.29
申请号
WO2005EP57102
申请日期
2005.12.22
申请人
ALGRY QUIMICA, S. L.;DIAZ MARTINEZ, ADOLFO;RAFECAS JANE, LLORENC;RIERA ESCALE, ANTONI;PASTO AGUILA, MIREIA;ECIJA QUERALT, MARTA