NOVEL POLYPEPTIDE AND THE USE THEREOF

摘要

It is intended to provide a variety of useful polypeptides. Particularly, a polypeptide comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, an amide form thereof or a salt thereof can be used as a preventive/therapeutic agent for low blood pressure, a preventive/therapeutic agent for obesity, hyperphagia or the like, a preventive/therapeutic agent for lethargy, time-zone change syndrome (jet lag) or the like, a preventive/therapeutic agent for infertility and the like. A compound that promotes the activity of a polypeptide comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by any of SEQ ID NOS: 7 to 12 and 37 to 42, a partial peptide of the polypeptide or a salt of the polypeptide, or a salt of the compound is useful as a preventive/therapeutic agent for, for example, climacteric disorder or hyperthyroidism. A compound that inhibits the activity of the polypeptide or a salt of the compound is useful, for example, as a preventive/therapeutic agent for infertility or thyroid insufficiency.