发明名称 |
DETECTION OF A THERAPEUTIC ANTIBODY IN AN EXPERIMENTAL ANIMAL |
摘要 |
The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. |
申请公布号 |
WO2006066912(A2) |
申请公布日期 |
2006.06.29 |
申请号 |
WO2005EP13849 |
申请日期 |
2005.12.22 |
申请人 |
F. HOFFMANN-LA ROCHE AG;LENZ, HELMUT;STUBENRAUCH, KAY-GUNNAR |
发明人 |
LENZ, HELMUT;STUBENRAUCH, KAY-GUNNAR |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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