发明名称 |
Modified hirudin proteins and t-cell epitopes in hirudin |
摘要 |
The invention concerns hirudin and in particular modified forms of hirudin with improved properties. The improved proteins contain amino acid substitutions at specific positions. The invention provides modified hirudin with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
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申请公布号 |
US2006140929(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
US20050560918 |
申请日期 |
2005.12.16 |
申请人 |
BAKER MATTHEW;WATKINS JOHN |
发明人 |
BAKER MATTHEW;WATKINS JOHN |
分类号 |
A61K38/48;A61K38/58;C07H21/04;C07K14/815;C12N9/48;C12P21/06 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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