DEPOSITION OF SAMPLES AND SAMPLE MATRIX FOR ENHANCING THE SENSITIVITY OF MATRIX ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY

摘要

The present invention relates to small sample spots for MALDI targets and methods for producing the same. The sample spots are composed of a layer of matrix material and a layer of analyte. In some instances, the samples spots have diameters of no more than 50 micrometers or even smaller. The sample spots are deposited onto a MALDI target substrate using ultrasonic deposition from a nozzle.