发明名称 |
Liposomes containing oligonucleotides |
摘要 |
It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (SEQ. ID. NO: 1) wherein only the end bases are phosphorothioated is a preferred embodiment. Antisense sequences of up to 40 bases which contain this sequence, such as 5'-CCTGTATGTGCTCCATTGATGCAGC-3' (SEQ ID NO: 2) may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.
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申请公布号 |
US2006141020(A1) |
申请公布日期 |
2006.06.29 |
申请号 |
US20040010158 |
申请日期 |
2004.12.10 |
申请人 |
GEORGETOWN UNIVERSITY |
发明人 |
KASID USHA;GOKHALE PRAFULLA;ZHANG CHUANBO;DRITSCHILO ANATOLY;RAHMAN AQUILUR |
分类号 |
A61K48/00;A61K9/127;A61K38/00;C07H21/00;C12N15/113;C12N15/88 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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