发明名称 |
Compositions of estrogen-cyclodextrin complexes |
摘要 |
Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and <-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity. |
申请公布号 |
ZA200305532(B) |
申请公布日期 |
2006.06.28 |
申请号 |
ZA20030005532 |
申请日期 |
2003.07.17 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
THOMAS BACKENSFELD;WOLFGANG HEIL;RALPH LIPP |
分类号 |
A61K;A61K31/565;A61P15/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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