发明名称 |
ANTIBODY RECOGNIZING TGF-BETA ACTIVATION CONTROLLING REGION SECTION |
摘要 |
It is an object of the present invention to provide antibodies capable of detecting an active TGF-² generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-²) generated as a result of generation of active form of human TGF-²1, human TGF-²2 and human TGF-²3. The antibodies are able to specifically recognize respective cutting edges within protease cleavage sites existing in the region from the amino acid residue glycine at position 51 to the amino acid residue arginine at position 110 of human TGF-²1, and corresponding regions of human TGF-²2 and human TGF-²3.
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申请公布号 |
EP1674480(A1) |
申请公布日期 |
2006.06.28 |
申请号 |
EP20040772928 |
申请日期 |
2004.09.03 |
申请人 |
RIKEN |
发明人 |
KOJIMA, SOICHI;KONDO, WAKAKO;DOHMAE, NAOSHI |
分类号 |
C07K16/24;C12N15/19;C12P21/08;G01N33/53;G01N33/68;(IPC1-7):C07K16/24 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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