Process for obtaining enantiomers of cizolirtine

摘要

A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1 H -pyrazol-5-yl)methoxy]- N,N- dimethylethanamine and its enantiomers, it comprises the asymmetric reduction of a prochiral ketone in the presence of a chiral ruthenium (II) catalyst system comprising at least a bidentate phosphorous-containing ligand and a diamine ligand to render chiral alcohols. The chiral alcohols are further O-alkylated to render the corresponding pharmaceutically active ethanamines.