发明名称 |
USE OF GENETIC POLYMORPHISMS THAT ASSOCIATE WITH EFFICACY OF TREATMENT OF INFLAMMATORY DISEASE |
摘要 |
<p>The MHC III region of chromosome 6p21.3 harbors a DNA sequence, most likely within the TNF or LTA gene, which influences response to pimecrolimus for the treatment of atopic dermatitis. Accordingly, genetic polymorphisms in the TNF and LTA genes are useful as biomarkers of the efficacy of pimecrolimus treatment of inflammatory disease. By contrast, response to tacrolimus appears to be influenced by other biological pathways.</p> |
申请公布号 |
EP1673473(A1) |
申请公布日期 |
2006.06.28 |
申请号 |
EP20040765831 |
申请日期 |
2004.10.05 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH |
发明人 |
IDE, SUSAN;LAVEDAN, CHRISTIAN, NICOLAS;MCCULLOUGH, KAREN |
分类号 |
A61K49/00;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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