发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) |
摘要 |
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
申请公布号 |
HU0600225(A2) |
申请公布日期 |
2006.06.28 |
申请号 |
HU20060000225 |
申请日期 |
2002.06.13 |
申请人 |
GENMAB A/S |
发明人 |
VAN DE WINKEL, JAN;VAN DIJK, MARCUS A.;GERRITSEN, ARNOUT F.;HALK, EDWARD |
分类号 |
A01K67/027;C07K16/28;A61K31/17;A61K31/196;A61K31/675;A61K31/704;A61K33/24;A61K39/395;A61K45/00;A61K47/48;A61P35/00;A61P37/04;A61P43/00;C07K16/22;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12N15/63;C12P21/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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