| 发明名称 |
USE OF GENETIC POLYMORPHISMS TO PREDICT DRUG-INDUCED HEPATOTOXICITY |
| 摘要 |
<p>IL1A or a gene located near IL1A on chromosome 2q14 may contribute to hepatotoxicity, as measured by increased serum levels of aspartate transaminase, during N-benzoyl-staurosporine treatment for macular edema. Accordingly, genetic polymorphisms in the IL1A gene are useful as biomarkers for predicting staurosporine derivative-mediated hepatotoxicity.</p> |
| 申请公布号 |
EP1673472(A1) |
申请公布日期 |
2006.06.28 |
| 申请号 |
EP20040765830 |
申请日期 |
2004.10.05 |
| 申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH |
发明人 |
MCCULLOUGH, KAREN;WOLFGANG, CURT, DOUGLAS |
| 分类号 |
C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
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