Virus preparations

摘要

1,125,210. Medicinal virus preparations. AMERICAN HOME PRODUCTS CORP. 16 Aug., 1967 [31 Aug., 1966], No. 37599/67. Heading A5B. [Also in Division C6] A dosage form for the immunization of the intestinal tract with live virus preparations comprises; an inner pressed tablet containing at least one pharmaceutically acceptable solid excipient and a live virus capable of infecting the intestinal tract; an intermediate pressed layer, containing at least one pharmaceutically-acceptable solid excipient, completely encasing the inner pressed tablet and providing a shell which per se has a minimum wall thickness of 0.03 inch; and an outer enteric coating material completely covering the intermediate pressed layer. According to an example, lyophilised solids obtained by the freeze-drying of filtered adonovirus type IV in the presence of skim milk, gelatin and human serum albumin, were tabletted with a mixture of lactose, microcrystalline cellulose and magnesium stearate. The tablets were then press coated with a similar mixture and to the press-coated tablets there was applied an enteric coating solution prepared by admixing cellulose acetate hydrogen phthalate and castor oil with acetone and absolute alcohol. The inner pant or core may be either a compressed tablet of lyophilised material or a compressed tablet of solid material containing adsorbed liquid virus e.g. virus-containing fluids adsorbed on sugar or resins. Other viruses which can be incorporated in Ithe press-coated tablets are influenza, parainfluenza, rhinoviruses and other viruses whose primary infection site is not the intestine.