| 摘要 |
The present invention relates to compounds comprising the following formula: <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>0</SUP>-Q-X-Q'-W-U-V-G-M (I)<?in-line-formulae description="In-line Formulae" end="tail"?> These compounds are useful as pharmacologically active compounds. They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders such as thromboembolic diseases or restenoses. These compounds are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can generally be used to treat, prevent, or cure conditions in which an undesired activity of factor Xa and/or factor VIIa is present, or where inhibition of factor Xa and/or factor VIIa is intended. The invention further relates to processes for the preparation of these compounds, methods of their use (e.g., as active ingredients in pharmaceuticals), and pharmaceutical preparations comprising them.
|
