发明名称 |
A METHOD FOR THE PREPARATION OF ENANTIOMERICALLY PURE MIRTAZAPINE |
摘要 |
<p>The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirtazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.</p> |
申请公布号 |
LT2005107(A) |
申请公布日期 |
2006.06.27 |
申请号 |
LT20050000107 |
申请日期 |
2005.12.12 |
申请人 |
AKZO NOBEL N. V. |
发明人 |
WIERINGA, JOHANNES, HUBERTUS;VAN DE VEN, ADRIANUS, ANTONIUS MARTINUS;KEMPERMAN, GERARDUS, JOHANNES |
分类号 |
C07D401/00;C07D401/04;C07D471/00;C07D471/14 |
主分类号 |
C07D401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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