发明名称 |
Compositions that bind antiterminator RNA and assay for screening for such compositions |
摘要 |
Compounds that are selective binding agents specific for RNA secondary and tertiary structures and a fluorescence assay for detecting the binding of small molecules to T-box antiterminator model mRNAs. The compounds include novel tri-substituted oxazolidinones and amino alcohols. The assay provides fluorescently labeled model mRNAs that include conserved sequence information typical of antiterminator bulge regions found in the mRNA of T-box gene regulatory systems.
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申请公布号 |
US2006135579(A1) |
申请公布日期 |
2006.06.22 |
申请号 |
US20050257471 |
申请日期 |
2005.10.24 |
申请人 |
OHIO UNIVERSITY |
发明人 |
HINES JENNIFER V.;BERGMEIER STEPHEN C.;HENKIN TINA M.;GRUNDY FRANK J. |
分类号 |
A61K31/421;C07C215/10;C07C215/20;C07C215/28;C07C217/64;C07D263/24;C07D263/38 |
主分类号 |
A61K31/421 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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