| 摘要 |
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with I module, and a cytochrome P450 hydroxylase is described. Also provided are novel Streptomyces species and methods of modified Streptomyces species. Further described are novel compounds, 36-ketomeridamycin, C9-deoxomeridamycin, and C9-deoxoprolylmeridamcyin and uses thereof. |
| 申请人 |
WYETH;HE, MIN;HUCUL, JOHN;HALTLI, BRADLEY, ARNOLD;WAGENAAR, MELISSA, M.;GRAZIANI, EDMUND;SUMMERS, MIA;KULOWSKI, KERRY;PONG, KEVIN;FENG, XIDONG |
发明人 |
HE, MIN;HUCUL, JOHN;HALTLI, BRADLEY, ARNOLD;WAGENAAR, MELISSA, M.;GRAZIANI, EDMUND;SUMMERS, MIA;KULOWSKI, KERRY;PONG, KEVIN;FENG, XIDONG |
