| 摘要 |
A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula: wherein R<SUB>1 </SUB>is selected from the group consisting of OSO<SUB>2</SUB>CF<SUB>3</SUB>, OSO<SUB>2</SUB>CH<SUB>3</SUB>, SO<SUB>2</SUB>R<SUB>3</SUB>, COCF<SUB>3</SUB>, COCH<SUB>3 </SUB>and COCH<SUB>2</SUB>CH<SUB>3</SUB>, wherein R<SUB>3 </SUB>is as defined hereafter; R<SUB>2 </SUB>is selected from the group consisting of C<SUB>1</SUB>-C<SUB>4 </SUB>alkyls, allyl, CH<SUB>2</SUB>CH<SUB>2</SUB>CH<SUB>2</SUB>F, CH<SUB>2</SUB>CF<SUB>3</SUB>, 3,3,3-trifluoropropyl and 4,4,4-trifluorobutyl; R<SUB>3 </SUB>is selected from the group consisting of C<SUB>1</SUB>-C<SUB>3 </SUB>alkyls, CF<SUB>3</SUB>, and N(CH<SUB>3</SUB>)<SUB>2</SUB>; with the proviso that when R<SUB>1 </SUB>is SO<SUB>2</SUB>R<SUB>3 </SUB>and R<SUB>3 </SUB>is a C<SUB>1</SUB>-C<SUB>3 </SUB>alkyl, then R<SUB>2 </SUB>is not CH<SUB>2</SUB>CH<SUB>2</SUB>OCH<SUB>3</SUB>; or a pharmaceutically acceptable salt thereof are provided. Also, pharmaceutical compositions comprising the above compound and methods wherein the above compound is used for the treatment of various disorders are provided.
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