Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative,and inflammatory disorders

摘要

The present invention provides compounds of the following structure, wherein R₁, R₂, R₄, R_4', R₆, R₇, and R₁₅ are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.