Peptides and related molecules that bind to TALL-1

摘要

The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz²Lz⁴ wherein z² is an amino acid residue and z⁴ is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO:100) a¹a²a³CDa⁶La⁸a⁹a¹⁰Ca¹²a¹³a¹⁴, (SEQ. ID. NO:104) b¹b²b³Cb⁵b⁶Db⁸Lb¹⁰b¹¹b¹²b¹³b¹⁴Cb¹⁶b¹⁷b¹⁸ (SEQ. ID. NO:105) c¹c²c³Cc⁵Dc⁷Lc⁹c¹⁰c¹¹c¹²c¹³c¹⁴Cc¹⁶c¹⁷c¹⁸ (SEQ. ID. NO:106) d¹d²d³Cd⁵d⁶d⁷WDd¹⁰Ld¹³d¹⁴d¹⁵Cd¹⁶d¹⁷d¹⁸ (SEQ. ID. NO:107) e¹e²e³Ce⁵e⁶e⁷De⁹Le¹¹Ke¹³Ce¹⁵e¹⁶e¹⁷e¹⁸ (SEQ. ID NO:109) f¹f²f³Kf⁵Df⁷Lf⁹f¹⁰Qf¹²f¹³f¹⁴ wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X¹)_a-V¹-(X²)_b wherein V¹ is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.