A HUMAN CELL ASSAY TO DETERMINE EFFECT OF SAMPLE COMPOUNDS ON COL2 ENHANCER EXPRESSION

摘要

This invention relates to human chondrocyte activity (growth)/differentiation/production of extracellular matrix) and to the effect of Sox9transcription factor and Colt enhancer as a measure for such activity. It also relates to a chimeric cell and assay utilizing such cell useful in predicting the effect of sample compounds on chondrocyte activity as measured by Sox9 and Colt expression/activity.