发明名称 METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS
摘要 A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1<->/Pax6<+> in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6<+>/Sox1<+>.
申请公布号 EP1670901(A2) 申请公布日期 2006.06.21
申请号 EP20040782339 申请日期 2004.08.27
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION 发明人 ZHANG, SU-CHUN;THOMSON, JAMES, A.;DUNCAN, IAN, DAVID;LI, XUE-JUN
分类号 C12N5/02;C12N;C12N5/0793;G01N33/48;(IPC1-7):C12N5/02 主分类号 C12N5/02
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