发明名称 |
METHOD OF IN VITRO DIFFERENTIATION OF NEURAL STEM CELLS, MOTOR NEURONS AND DOPAMINE NEURONS FROM PRIMATE EMBRYONIC STEM CELLS |
摘要 |
A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1<->/Pax6<+> in the presence of FGF2, FGF4, FGF8, FGF9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6<+>/Sox1<+>. |
申请公布号 |
EP1670901(A2) |
申请公布日期 |
2006.06.21 |
申请号 |
EP20040782339 |
申请日期 |
2004.08.27 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
ZHANG, SU-CHUN;THOMSON, JAMES, A.;DUNCAN, IAN, DAVID;LI, XUE-JUN |
分类号 |
C12N5/02;C12N;C12N5/0793;G01N33/48;(IPC1-7):C12N5/02 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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