Means and methods for determining and/or influencing cellular transportation

摘要

The invention provides a method for determining whether a compound or its metabolite can be secreted into the milk or colostrum of a lactating mammal through active transport by Breast Cancer resistance Protein if said compound or metabolite is circulating within said mammal, the method comprising determining whether said compound or metabolite is a substrate of Breast Cancer Resistance Protein. Said compound preferably comprises a nutrient, a medicament, a vaccine, a pesticide, a toxin and/or a carcinogen. A method for altering the capability of a compound of being secreted into the milk of a lactating mammal if said compound is circulating within said mammal, the method comprising altering at least part of said compound such that said compound's capability of being a substrate of Breast Cancer Resistance Protein is altered, is also provided.