发明名称 |
CANINE CYP1A2 GENE POLYMORPHISM |
摘要 |
Disclosed is a method for determining whether a dog is an extensive metabolizer or a poor metabolizer in the rate of drug metabolism, by preparing a DNA sample from a dog, and determining a base corresponding to a base at position 1117 of a canine CYP1A2 gene (i.e., at position 87 of exon 4). According to the method, a CYP1A2 gene diagnosis of dogs (particularly beagles) used in a pharmacological effect test or a toxicity test can be rapidly carried out prior to the test, and thus the dogs can be easily divided into a group having a normal metabolic ability (an extensive metabolizer group) and a group having a low metabolic ability (a poor metabolizer group). |
申请公布号 |
EP1672069(A1) |
申请公布日期 |
2006.06.21 |
申请号 |
EP20040745392 |
申请日期 |
2004.05.28 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
TENMIZU, DAISUKE;FUKUNAGA, YASUHISA;NOGUCHI, KIYOSHI |
分类号 |
C12N15/12;C12Q1/68;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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