Antibiotic-containing bone replacement material with retarding drug release

摘要

Antibiotic-containing bone substitute material comprises a compacted mixture of granules bound together with glycerol tripalmitate, glycerol tristearate, glycerol trilaurate or 1-hexadecanol. The granules comprise calcium sulfate dihydrate; another mineral; and an aminoglycoside, lincosamide, glycopeptide, macrolide, ketolide, nitroimidazole, fluoroquinolone, oxazolidinone, steroidal, antiseptic or fungicidal/fungistatic antibiotic. Antibiotic-containing bone substitute material comprises a compacted mixture of granules bound together with glycerol tripalmitate, glycerol tristearate, glycerol trilaurate or 1-hexadecanol. The granules comprise calcium sulfate dihydrate; calcium carbonate, beta -tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, magnesium carbonate, trimagnesium phosphate, magnesium hydroxide or magnesium oxide; and an aminoglycoside, lincosamide, glycopeptide, macrolide, ketolide, nitroimidazole, fluoroquinolone, oxazolidinone, steroidal, antiseptic or fungicidal/fungistatic antibiotic. ACTIVITY : Antimicrobial; Fungicide; Osteopathic. MECHANISM OF ACTION : None given.