| 摘要 |
<p>Transdermal plaster (A) containing progesterone A-specific ligands (I) as active substance, comprises a back layer, at least a coupling, active substance containing adhesive layer (based on e.g. silicone polymer) and a removable protective film, where the concentration of the active substance is 0.1-10%, related to the total weight of the adhesive matrix. Transdermal plaster (A) containing progesterone A-specific ligands of formula (I) or their derivatives or descendants as active substance, comprises a back layer, at least a coupling, active substance containing adhesive layer (based on silicone polymer, polyisobutylene polymer, polyacrylate polymers or styrol block copolymer with butadiene or isoprene) and a removable protective film, where the concentration of active substance is 0.1-10%, related to the total weight of the adhesive matrix. R 1, R 2H or F; R 3CH 3 or CF 3; and Ar : 4-methyl-benzo[d][1,2]oxazin-1-one-6-yl or 3H-isobenzofuran-1-one-5-yl. An independent claim is also included for the preparation of (I). [Image].</p> |
